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scRNA-seq analysis, cluster identification, and gene marker determination Data of each individual experiment was analyzed according to the following steps: Raw sequencing data was aligned to the mouse reference genome (GRCm39) and quantified using cellranger count (10 Genomics)

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These include its comparatively high utilization of oxygen and therefore generation of free radical byproducts, its modest antioxidant defenses, its lipid-rich constitution that provides substrates ready for oxidation, the reducing potential of certain neurotransmitters, and the presence of redox-catalytic metals, like iron and copper (47)

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